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Mantle cell lymphoma

3 associated genes
7 signs/symptoms

PROTEIN INTERACTIONS: 1

Generalized resistance to thyroid hormone

2 OMIM references -
1 associated gene
8 signs/symptoms

Mantle cell lymphoma

Generalized resistance to thyroid hormone

ATM	(UniProt - OMIM)		THRB	(UniProt - OMIM)
CCND1	(UniProt - OMIM)
IGH	(UniProt)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CCND1	(0.79)	THRB

Citations in the biomedical literature:

Mantle cell lymphoma		Generalized resistance to thyroid hormone
	Synonym(s): - LCM - MCL - Mantle zone lymphoma		Synonym(s): - Deafness - thyroid hormone resistance - Refetoff syndrome

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare otorhinolaryngologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial		Epidemiological data: (no data available)

	External references: No OMIM references 1 MeSH reference: D020522		External references: 2 OMIM references - No MeSH references

Mantle cell lymphoma		Generalized resistance to thyroid hormone
	Very frequent - Hematologic / blood / lymphatic cancer - Lymphadenopathy / polyadenopathies Frequent - Anorexia - Asthenia / fatigue / weakness - Bone marrow / medullar infiltration - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Autosomal recessive inheritance - Beaked nose - Delayed bone age - Pectus carinatum - Punctate epiphyses / epiphysis - Scapula structural / position anomaly / congenital elevation / Sprengel anomaly - Sensorineural deafness / hearing loss - Thyroid anomalies